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the national scientific and technical research council argentina selected biotechnology offer

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human and animal health oncology immunology vaccines the national scientific and technical research council spanish acronym conicet is the main government agency dedicated to promoting science and technology in many areas of knowledge -agriculture -engineering and materials -biology and health -exact and natural science -social and human science currently conicet has more than 6500 researchers 8100 fellows 2300 technicians 700 administrative employees and 164 research institutes regarding biotechnology conicet has 39 institutes where investigators ph.d and post-doctoral fellows perform their research in areas like plant biotechnology probiotics functional food biofuels biomaterials brioremediation biomining proteomics genomics genetic engineering molecular biology antitumour vaccine modified immunogen based on the thomsen-friedenreich disaccharide tfd in this innovation due to glycane engineering the immunogen presents increased antitumoural immunity and the capacity to inhibit the adhesion of tumour cells and their metastatic ability antitumour treatment vectors containing a dna fragment isolated from the secreted protein acidic and rich in cysteine sparcpromoter used for directing a heterologous gene expression in tumour cells the first developed vector is called adf512 which replicates and eliminates melanomas and ovary tumours established in nude mice gene therapy vector for targeting tumours the current technology describes a genetic construct based on the capacity of a synthetic sequence to measure the levels of reactive oxygen species ros in a given disease with a toxic product that has been genetically cloned downstream to eliminate tumours monoclonal antibody for angiogenesis disorders monoclonal antibody that selectively targets gal-1 preventing or disrupting gal-1-glycan interactions attenuating hypoxiadriven angiogenesis while promoting extensive remodeling of vascular networks and simultaneously potentiating t-cell mediated antitumour immunity this technology is in co-titularity with dana-farber cancer institute patent manager dana-farber cancer institute contact dana-farber cancer institute 450 brookline avenue boston ma 02215 phone 866 408-dfci 3324 development of attenuated viral strains methodology for producing attenuated viral strains with stable phenotypic and genotypic characteristics different from that of the wild type strain for the formulation of vaccines and pharmaceutical compositions against a wide spectrum of enveloped virus.

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novel oral vaccine against intestinal parasitic protozoa oral vaccine against giardiasis composed by the complete repertoire of variant-specific surface proteins vsps of giardia this oral vaccine induces long­term protection against infections by giardia and it is the first protein­ based vaccine that can be orally administered and does not require cold chain for maintenance and transport controlled release water soluble pharmaceutical composition injectable aqueous sterile compositions formed by nanomicelles of glycosphingolipids and/or modified glycosphingolipids these nanomicelles allow the delivery and controlled release of highly hydrophobic molecules which are active therapeutic substances medical devices methods method to identify sexually premature calves method for identifying bovines that are expected to reach puberty at an early age by detecting the presence of single nucleotide polymorphisms snps in lhr y gnrhr genes the detection of these particular snps is directly related to sperm concentration and motility at early stages of bovine puberty sexually premature calves are able at younger ages to successfully fecundate cows which means important economic benefits to bull breeders methods for early diagnosis of diabetes immunologic methods for early diagnosis of type 1 diabetes mellitus and latent autoimmune diabetes in adults lada including technologies to produce the recombinant proteins gad and a-2ic type 1 diabetes mellitus markers and diagnostic support for early detection of the disease in prokaryotic systems like escherichia coli novel platform for oral vaccine production platform for oral or mucosal vaccine production using giardia variant-specific surface proteins vsps can be used by the oral route as a carrier of heterologous antigens of interest such polypeptides resistant to intestinal proteases changes in temperature different phs and with the capacity to attach to epithelial cells of the gut are able to shuttle a candidate antigen through the digestive tube to the intestine where it may stay for a time allowing the development of a strong local and systemic immune response method for estrous induction injectable microparticle for estrous induction in mammalian females this microparticle permits controlled release of one or more hormones like progesterone and induces estrous with only one application diagnosis of physiologic status and selection of the best spermatozoa device for diagnosis of physiologic status and/or selection of the best spermatozoa of a semen sample based on chemotaxis it may be employed in assisted fertilization techniques screening behavioral profiling to identify neurodegenerative targets method for the identification of genes involved in neurodegeneration by means of a systematic genetic screen based on the assessment of a progressive behavioral phenotype as a function of time in young and aged transgenic animals carrying the same mutation it can be used in the screening of drugs with antineurodegenerative effect and to generate new models of diseases therapeutic formulation for autoimmune or chronic inflammatory diseases method for preparing a therapeutic formulation which comprises galectin-induced tolerogenic dendritic cells tolerogenic dendritic cells negatively regulate t cells preventing the development of adaptive immune response this formulation can be used to treat autoimmune or inflammatory diseases.

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probiotics prevention of urogenital infections development of vaginal native lactobacillus to be used in the prevention and treatment of vaginal infections plant biotech prevention of bovine mastitis lactic bacteria strain applied on bovine mammary glands to prevent mastitis in cattle the antimicrobial activity is based on the production of organic acid hydrogen peroxide and bacteriocins biodegradable material for use in food pharmaceuticals cosmetics and cleaning products edible biodegradable biocompatible and non­toxic material composed by starch nano-crystals immersed in a tapioca starch matrix which may be used in the form of foils sheets films coatings gels etc to isolate and/or to protect a product from the environment it can be used in pharmaceutical food or cosmetics transgenic plants improved in abiotic stress tolerance and increased yield dna construct that is able to confer multiple abiotic stress tolerance to transgenic plants these transgenic plants show longer periods of survival to severe drought high salinity treatments submergence and water-logging also this technology ensures increased yield in any environmental condition prevention of gastritis probiotic lactic bacteria strain that is effective both to prevent and to treat gastritis it is based on the production of specific exopolysaccharides which are reported to be immunoregulators and have antiulcer properties this product may be presented as fermented milk prevention of bovine metritis innovative treatment to prevent bovine metritis based on an intravaginal infusion containing among other components probiotic lactic bacteria obtained from the native microbiota of healthy cow s vaginas these bacteria were specifically chosen for their ability to inhibit pathogen microorganism growth microbial biosensor for biological oxygen demand bod device consisting of a microorganism matrix that allows measuring accurately bod in water in a short time and without the need of diluting the sample it is intended to be used for industrial effluents monitoring environmental impact studies liquid effluent treatment facilities and bioremediation prevention of intestinal infections in young calves multi-strain lactic bacteria product to prevent intestinal infections in suckling calves which constitutes the major cause of cattle mortality this product may be presented as fermented milk bio industry lactic cultures to develop fermented beverages based on whey use of specific lactic cultures to produce fermented beverages starting from whey which can be employed as ingredient in the functional food industry biopreservant lactic cultures to be used in the baking industry application of specific ferments possessing antifungal properties altogether with compatible-substrate ingredients to be used in the bakery industry as biopreservants replacing the traditional chemical ones and extending bread s shelf-life.

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conicet technology transfer office 2358 rivadavia ave 4to floor c1034acp buenos aires city argentina phone 54-11 4951-7172 4611 7137 vinculacion@conicet.gov.ar www.conicet.gov.ar

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