ตัวอย่างผลงานการจัดโครงการ Dent Journal Club

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งานวิจัย :: ตัวอย่างผลงานการจัดโครงการ Dent Journal Club คณะทันตแพทยศาสตร์ มศว

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design of polymeric nanoparticles for the encapsulation of monoacylglycerol journal colloid and polymer science 2010 by paramaporn chiewpattanakul ph.d biomedical science faculty of medicine srinakharinwirot university ph.d engineering process and product nancy university france

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drug delivery system · technology of drug delivery · process to deliver drug drug vehicle drug · liposome emulsions · micro nanoparticle · drug vehicle nanoparticle 1000 nm

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nanoparticle surfactants hydrophobic part

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nanoparticle water water drug water

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advantages of using nanoparticle in drug delivery system 1 to prolong the action of drugs or biomolecules 2 to arrive at the specific target nanoparticle incoporate tumour-specific molecule interact specificity to cancerous cell brannon-peppas and blanchette 2004 3 to be able of controlled release properties 4 to reduce drug toxicity

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micro nanoparticle due to the disorganised tumour vasculature

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drug monoacylglycerols mags hhhhcccho oh oh ocrr hydrocarbon chain of fatty acid surfactants

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mags-surfactants · reducing the surface tension between oil and water as detergent emulsifier · making various advantages in many fields such as food industry cosmetic pharmaceutics rzicka et al 2003

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mags-biosurfactants report to isolate candida ishiwadae · a thermotolerant yeast from plant material in thailand · produced biosurfactants exhibited high surfactant activity · structures monoacylglycerols thanomsub et al 2004

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mags-biosurfactants · produced by microorganisms such as bacteria fungi and yeast · their properties same as surfactant structure more diverse biodegradable less toxicity low irritancy compatibility with human skin camilios et al 2008 pornsunthorntawee et al 2009

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monoacylglycerols · anticancer thanomsub et al 2004 philippoussis et al 2003 · antimicrobial bergsson et al 2002 bergsson et al 2001 bergsson et al 1999 bergsson et al 1998

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material used to apply in nanoparticle 1 hydrophobic polymers eg poly lactic acid pla 2 modification of nanoparticle surface with hydrophilic layer water eg.modified polysaccharides different hydrophilic backbones varied bearing hydrophobic water durand et al in lcpm laboratory nancy-france studying the properties of modified dextran drug water

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· dexp20 dextran bearing with phenoxy group modifed molecule compare with non modified molecule =20 o oh ho oh oh ho o q o ch2 ch ch2 o oh o p o structure of dexp20 dextran bearing phenoxy group with q p+q 20

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·dexc10164 dextran bearing with hydrophobic group n-c10h21 modifed molecule compare with non modifed molecule =164 o oh ho oh oh ho o q o ch2 ch ch2 ch3 9 o p o oh structure of dexc10164 dextran bearing hydrophobic group n-c10h21 with q p+q 164

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material used to apply in nanoparticle 3 two conjugated compounds modified polysaccharides polymers eg dexp20 pla or dexc10164 for modification the polarity of the nanoparticle core to gain more efficiency in attaching with various polarity encapsulated molecule water pla pla water pla pla drug pla pla water

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