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sependipity serendipity serendipity horace wolpole 1717-1797 1754 3 the three princes of serendip 3 louis pasteur 1822-1895 albert szent-gyorgyi 1893-1986 1937 discovery consists of seeing what everybody has seen and thinking what nobody has thought claude bernard 1813-1878 1865 virchow darwin 19 40

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1 3 5 7 9 11 13 15 clausenamide 17 19 21 tes 23 5 25

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50 14 100 7 73.7 21 72 2 5 66 40 58 56 34 43 29 21 7 50 38 11 38 15 15 42 26 16 21 16 9 5 71 57 50 7 14 1-

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64 42 35 100 43 57 85 64 28 2 12 2006 39

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1 2 1 hoffer1 2 90 90 :horizon horizon slide ratio 1 stat view 5.0 5 1 slide ratio horizon horizon 2 adl 30 2 0 1 etac 20 30 3 35 0 5 10 15 20 5 20 3 15 20 20 0 stat view 5.0 3-

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5 1 free time <0.05 1.2 8 7 6 5 4 3 2 1 0 15 <0.01 3 50 40 30 20 10 0 0 5-20 n.s n.s free:90min ht:90min 5 10 15 20 1 25 20 15 10 5 0 horizontal change degree twist degree slide ratio 0.05 3 n.s 0.01 free:90min ht:90min 0.05 2 adl adl 2 10 1 2006 2 hallenborg s.c wheelchair needs of the disabiled therapeutic considerations for the elderly churchill livingstom pp93-111 1987 3 7 7 26 2010 4-

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65 23.5 20.1 17 33.4 21 32.2 27.0 1 7214 6352 21 2000 17 6 11 1 n=11 n 6 62.3 ± 2.9 61.0 ± 3.7 cm 156.5 ± 2.3 164.0 ± 4.3 159.7 ± 5.0 kg 53.5 ± 6.3 67.3 ± 7.9 59.4 ± 9.8 ± n 17 61.7 ± 3.3 lifecorder gs ex 10 1 1 2 3 3 2 1 5107.3±909.6 4941.8±616.3 5328.0±1157.1 1 16 22 5 21 1 9,200 8,300 5-

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70 6,700 5,900 1 10 1000 40 40 1 2 20 20 20063 3 15 1 30 2 2006 3 13 3mets 4mets 1 1 3 1 ayabe m yoshioka m yahiro t higuchi h higaki h tanaka h objectively measured age-related changes in the intensity distribution of daily physical activity in adults j phys act health 64 419-425 2009 2 dunn al bh marcus jb kampert et al comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness jama 1999 3 21 4 55:229-236 2006 5 8:113-116 2007 6 3 554:385-392 2006 6-

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1 2 1 2 1 2005 2006 qol qol qol 2 1 87 18 69 82.3 ± 8.6 5.6 ± 4.7 2 a od 1 maranz pmd660 audio-technica atm31a rsst wst drace miura 20072 qol general oral health index gohai qolsf-8 20053 qol adl20 adlhds-r 3 hp compaq dc5850 os windows vista 3700 kay pentax ppq apq ftri nhr sub-harmonic dsh nsh od 1 qol od 1 sd /pa /ta /ka 3 3 /pataka 1 1 2 2 adl20 hds-r rsst mpt wst 3 1 mpt od ppqapq nhr p0.05 1 ftri sub-harmonic dsh nshsf-8 ghbp vt rpgohai p0.05 2 7-

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1 mpt ppq apq nhr 0.328 0.270 0.215 od /pa 0.113 0.190 0.323 /ta 0.289 0.199 0.317 /ka 0.284 0.191 0.338 /pataka 0.009 0.136 0.203 p<0.01 p<0.05 2 /qol ftri rp sf-8 bp gohai vt gh 0.281 0.160 0.411 0.300 0.035 dsh 0.049 0.237 0.214 0.117 0.358 nsh 0.094 0.318 0.218 0.121 0.377 p<0.01 p<0.05 1 od rsst mpt rsstmptadl20hds-r 0.05 1 drace <0.05 4 7 2 qol qol qol od hds-r adl20 adl od /pa /ta /ka /pataka od qol 1 2009 2miura h et al evaluation of chewing and swallowing disorders among frail community-dwelling elderly individuals j oral rehabil 34 422-427 2007 3 qol sf-8sf-36 213 133-136 2005 8-

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