Technical Profile Medicallife

 

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Technical Profile Medicallife

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Technical profile

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with Active Plant Stem Cells with Active Plant Stem Cells Anti-Ageing Anti-Ageingface faceCream Cream exclusive patented Display of 9 pieces A rich emulsion that prevents and fights the signs of skin ageing, thanks to a cocktail of active ingredients with antioxidant, elasticizing and nourishing properties. The texture, rich but not greasy, is quickly absorbed without leaving any greasy residue. ACTIVE INGREDIENTS AND RESULTS - Plant stem cells from Edelweiss From Medicallife research the first selection of stem cells from Edelweiss, a concentrate of active ingredients of the plant, for maximum results on the skin. The stem cells are produced through the use of leaves of the plant cultivated organically, to guarantee the most absolute respect for nature and the environment. Thanks to the special technique of extraction and cultivation used by Medicallife, the product is rich in Leontopodic Acid of type A and B, Chlorogenic Acid and 3.5 Dicaffeoylquinic Acid, the antioxidant action of which is far greater than the substances normally used for this purpose. Below, the TEAC test which evaluates the antioxidant capacity compared to Trolox (antioxidant substance used as reference to which a   of 1 is given). value In addition to an antioxidant action, the active ingredients of the Edelweiss play a fundamental role in effectively inhibiting the enzyme collagenase and the enzyme hyaluronidase; the anti-collagenase and antihyaluronidase activity is analysed. . TEAC test   anti-collagenanase activity   anti-hyaluronidase activity   In the diagram evaluating the anti-hyaluronidase activity, you can note how the active complex of stem cells is more effective than the action of the Leontopodic Acid B. 12 2

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CLINICAL EVIDENCE - 20 Subjects - 2 daily applications of cream containing Edelweiss stem cells - Evaluation of subjects after 20 days of treatment - Area evaluated: eye contour The evaluation has been carried out with a cutaneous scanner, after 20 days a reduction of the depth of the wrinkles of 15% was obtained.     - Plant stem cells from red clover Red clover is a plant with multiple medicinal properties; its high content of phytohormones, in particular phytoestrogens, make it particularly suitable in slowing down ageing of the skin and mucous. The technique of cultivating the stem cells from red clover, adopted by the Medicallife laboratories, has allowed concentrating a high number of isoflavones with a phytoestrogen action in a natural way. Dadizein, Genistein, Formononetin and Biocanin are the main isoflavones contained in the stem cells.     They support the dermal trophism, which decreases with the advancing of age, through phytoestrogenic support for the tissues.   Properties - Immediate tensor effect - Increased skin tone - Reduction of oxidative stress - Diaminopropionoyl Tripeptide-33 A tetrapeptide identified and created to effectively fight the harmful effects of exposure to UV rays, responsible for photo-ageing. It is a second generation antioxidant with outstanding anti-free radical and detoxifying properties due to the reactive carbonylic compounds; in the diagram below the anti-trans 2 nonenal and anti-trans 4 hydroxynonenal capacities have been evaluated, compared to that of carnosine. The activity of our tripeptide is shown in green, far greater than that of carnosine.     3  

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EVIDENCE ON IN VITRO CULTURES The efficacy of Diaminopropionoyl Tripeptide-33 has been evaluated in vitro on cellular cultures of keratinocytes and fibroblasts. At the concentration of 1mg/ml, the product can protect the keratinocyte and fibroblast activity, keeping cellular proliferation active. Below are shown the data of protection of damage to the DNA: it can be noted how as the concentration of the molecule increases, there is a greater protection of the DNA; Reduction of the DNA TAIL (blue) and DNA DAMAGE.     Properties - Protective action from UV rays - Reduction of the cutaneous inflammatory response - Anti-ageing action - Argan Oil Extracted from the fruit of Argania spinosa, it is very rich in polyunsaturated fatty acids, like Omega 6 in a - pressure, concentration 3 times greater than olive oil. The process of extraction is only mechanically, by cold - influences to protect the stability of the oil and its fraction of Sterols and Vitamin E. Its particular composition the restoration of the NMF (Natural Moisturizing Factor) present on the epidermis.     - Commiphora mukul   A plant belonging to the family of the Burseraceae, it grows in north-east India and in Pakistan; a resin, obtained from an incision in its bark, contains a complex combination of active molecules, including sterols, aliphatic esters and diterpenoids. These include Commipherul and Commipherin, 2 molecules with a unique capacity to stimulate lipogenesis, helping the skin to regain lost tone. The result is that wrinkles are lifted and a natural and safe filler effect.   14 4

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    - Vitamin E protected - Vitamin A - Aloe vera - Shea Butter Emulsion riche qui permet de prévenir et de combattre les signes de vieillissement de la peau grâce au mélange de principes d’actifs aux propriétés antioxydantes, assouplissantes et nourrissantes. La texture, riche mais non grasse, est absorbée rapidement, sans laisser de résidus gras. Eine reichhaltige Emulsion, die den Anzeichen der Hautalterung vorbeugt und diese mit Hilfe von Wirkstoffen mit Antioxidans-, Elastizität und Nährstoffe verleihenden Eigenschaften bekämpft. Die reichhaltige, jedoch nicht fettige Texture wird schnell aufgenommen, ohne Fettrückstände zu hinterlassen. Una rica emulsión que previene y combate los signos del envejecimiento cutáneo gracias a una combinación de activos con propiedades antioxidantes, elastizantes y nutritivas. Su textura, rica pero no grasa, se absorbe rápidamente sin dejar residuos grasosos. Antioksidan, esnekleştirici ve besleyici özelliklere sahip aktif içeriklerin karışımı sayesinde, cildin yaşlanmasını geciktiren ve kırışıklıklarla mücadele eden zengin emülsiyon. Zengin ama yağlı olmayan dokusu sayesinde yapışmadan hızlı bir şekilde emilir. 5

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Neck and Décolleté Cream Neck and Décolleté Cream Neck and Décolleté Cream With Active Plant Stem Cells with Active Plant Plant Stem Cells With Active Stem Cells exclusive exclusive patented patented Display for 9 pieces Display for 9 pieces This cream with an intensive action and great emollient power has a rich, soft and comfortable texture and is particularly for very action dehydrated skins where there is has a loss of intercellular fluids and consequent This cream suitable with an intensive and great emollient power a rich, soft and comfortable texture and is phenomena of xerosis inflammation of the skin. particularly suitable foror very dehydrated skins where there is a loss of intercellular fluids and consequent phenomena of xerosis or inflammation of the skin. ACTIVE INGREDIENTS AND RESULTS ACTIVE INGREDIENTS AND RESULTS - Edelweiss plant stem cells cloverplant plantstem stemcells cells - Red Edelweiss asiatica plant cells stem cells - Centella Red clover plant stem - Centella asiatica plant stem cells   Called “tiger and elephant herb” because wild animals would roll in its leaves when injured to soothe their   Called “tiger and elephant herb” because wild animals would roll in its leaves when injured to soothe their wounds, it has many medicinal properties. Using stem cells, Medicallife has been able to concentrate these properties plant cell cultures rich in: wounds, it selecting has many medicinal properties. Using stem cells, Medicallife has been able to concentrate these properties selecting plant cell cultures rich in: - 3,5 dicaffeoylquinic acid tricaffeoylquinic acid - 1,3,5 3,5 dicaffeoylquinic acid stigmasterol - 1,3,5 tricaffeoylquinic acid polysaccharides - stigmasterol acids - amino polysaccharides - polyphenols amino acids - polyphenols The widely documented properties of Centella asiatica include an outstanding antioxidant, anti-hyaluronidase and activity. The anti-inflammatory widely documented properties of Centella asiatica include an outstanding antioxidant, anti-hyaluronidase Its antioxidant capacity compared to Trolox (a synthetic molecule used as reference) and Rutin has been and anti-inflammatory activity. assessed in this bar chart. Its antioxidant capacity compared to Trolox (a synthetic molecule used as reference) and Rutin has been assessed in this bar chart. The results show an activity that is 1.5 times greater than that of Trolox and Rutin. The results obtained in   vitro for inhibition of the hyaluronidase are shown The results show an activity that is 1.5 activity times greater than below. that of Trolox and Rutin. The results obtained in vitro for inhibition of the hyaluronidase activity are shown below.   6

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The anti-inflammatory capacity has been assessed by observing the influence of Centella asiatica on the release of TNF-a, involved in the inflammatory response. The result was compared with the activity of Rutin. Properties - Antioxidant, anti-ageing activity - Reduction in the skin’s inflammatory response - Anti-ageing action       - SOD   SOD   Superoxide dismutase is the enzyme that our organism produces to fight free radicals. At Medicallife, we have included the same enzyme in our Manù neck and décolleté cream so that it is 100% compatible with the skin. It catalyses the reaction that starts from radical oxygen and produces oxygenated water, which in turn will be neutralized by endogenous catalysis. - Ceramides These are composed of sphingosines and Fatty acids and carry out their action by being inserted into the intercorneocyte spaces of the epidermis. Here they allow an improved lubrication of the outer layer, giving the skin suppleness and compactness.   Epidermis: stratum corneum   Properties - Restructuring action - Elasticizing action - Improvement in the state of the skin’s hydration - Hyaluronic acid This is one of the main polysaccharide components of the extracellular matrix. Thanks to its properties, it can influence the cellular functions, modifying their surrounding micro- and macro-environment, through its complex interactions with the cells and with the other components of the extracellular matrix. Very recent studies have shown that the CD44 receptor is the main target of hyaluronic acid. Following this interaction, a number of physiological events are triggered off which include: cell-cell adhesion, cell-substrata adhesion, cellular migration, proliferation and activation and the uptake and degradation of hyaluronic acid..   At cutaneous level, the CD44 receptor has two main functions: - to regulate the proliferation of keratinocytes in response to extracellular stimuli - to maintain the homeostasis of hyaluronic acid 20 7

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Regulation of the proliferation of keratinocytes by Cd 44 receptor Connective tissue   Properties - Compacting action - Elasticizing action - Fibroblast stimulation - Esuronammina     Composed of constituents of the disaccharide unit of hyaluronic acid (i.e. glycuronic acid and acetylglucosamine), it has been included to increase the content of hexosamines and pentoses in the fundamental substance of connective tissue, with a regenerating action on the connective mucopolysaccharides: This action considerably improves the hydration of the tissues and helps absorption by the skin. - Limnanthes alba An oil rich in long-chain fatty acids is extracted from the seeds of this plant, with sebum-similar characteristics that give it an excellent skin absorption capacity through the corneocyte layer. It is a nonocclusive emollient, rich in natural antioxidants (gamma-tocopherol), capable of restoring the skin’s natural lipid barrier, giving suppleness and softness. As it is not very greasy, it is not felt on the skin.   Une texture riche, souple et douce, une crème avec une action intensive et un fort pouvoir émollient particulièrement indiqué pour prendre soin des peaux très déshydratées sur lesquelles on assiste à une perte de liquides intercellulaires et aux phénomènes consécutifs de xérosis ou inflammation cutanée. Eine reichhaltige, geschmeidige und schützende Texture, eine extrem weich und geschmeidig machende Intensivcreme, die sich besonders für die Pflege extrem feuchtigkeitsarmer Haut eignet, bei der eine Unterversorgung der Gewebsflüssigkeit mit daraus resultierender Xerose oder Hautentzündung auftritt. Con textura rica, suave y muy agradable, es una crema de acción intensiva con alto poder emoliente, particularmente indicada para el cuidado de la piel muy deshidratada que manifiesta pérdida de líquido intercelular y en consecuencia fenómenos de xerosis o inflamación cutánea. Özellikle hücreler arası sıvı kaybı ve bunun neticesinde olağanüstü kuruluk veya iltihaplanma durumlarının görüldüğü çok kuru ciltlerin bakımı için ideal, zengin, yumuşak ve cildi saran bir dokuya sahip yoğun yumuşatıcı etkili krem. 21 8

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Eye Contour Treatment Eye Contour Treatment exclusive patented This rich emulsion can guarantee a reduction in unsightly bags under the eyes and dark circles. The soft texture offers the skin a sensation of freshness, giving immediate benefit. Thanks to the perfect synergy of the active ingredients selected by Medicallife, the phenomenon is countered at several levels with a complete and effective action. ACTIVE INGREDIENTS AND RESULTS   - Pfaffia paniculata Also called Brazilian ginseng, the natives of Amazonia have used Pfaffia for generations for a wide range of uses: as an energizer and an aphrodisiac, to rejuvenate, as a tonic in general but often as a reinvigorating tonic; the presence of Pfaffic acid in a high concentration, together with a complex of Vitamins A, B1, B2, E, K, and mineral salts, allows obtaining a toning effect where necessary as in the case of bags under the eyes. Its action seems to be linked to its capacity to protect the capillary veins, helping to reduce the formation of dark areas.     25 9

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- Ptychopetalum olacoides Also called Marapuama or the love herb, it is another typical Brazilian plant used in particular for its beneficial effects on the circulation. Its properties are linked to numerous active substances such as Muirapuamine and other alkaloids, which are extracted from the resin obtained from the plant’s roots and bark. Its action seems to be linked to its particularly outstanding antioxidant capacity, which is believed to reduce the radical component formed during an inflammatory process. This contributes to a reduction of the phenomenon. Its effect is also believed to directly stimulate the fibroblast activity and increase the levels of SOD (superoxide dismutase) and Catalase, two enzymes which are fundamental in blocking the activity of radicals. -   - Lilium candidum Lilium candidum (or the Madonna lily), which has always been used topically to treat ulcers, rashes and burns, finds a perfect synergy with the active substances in the Medicallife formulation. Its anti-inflammatory properties appear to be linked to its capacity to reduce the levels of Phospholipase A2, Prostaglandin E1-E2 and other components of the arachidonic cascade. -   EVIDENCE ON IN VITRO CULTURES The properties of the three extracts (Pfaffia, Marapuama and Madonna lily) have been assessed in vitro in cellular cultures of keratinocytes, showing anti-inflammatory effects, fibroblast-stimulating activity, antioxidant and lipolytic effects, giving the following results: In this case the capacity of inhibiting the production of Prostaglandin E1 and E2 was measured.   Effect of reducing the formation of Histamine and Interleukin 10   26 10

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Assessment of the effect of the stimulation of the fibroblasts’ activity on the production of Collagen and Elastin   Effect on the release of free non-esterified fatty acid (NEFA)     The results have led to a 122% reduction in the shade of under-eye bags   Properties - Anti-inflammatory effect - Increase in resistance of the capillary veins - Reduction in oxidative stress - Increase in lipolytic activity - Fibroblast stimulation activity EVIDENCE ON IN VITRO CULTURES The effectiveness of the product was assessed on a sample of 21 women, after 28 days of treatment. - Hyaluronic acid This is one of the main polysaccharide components of the extracellular matrix. Medicallife’s special formulation has taken into consideration different types of hyaluronic acid with different molecular weights, thus guaranteeing a dual moisturizing and support effect for the dermis. Thanks to its properties, it can influence the cellular functions, modifying its surrounding micro- and macroenvironment, by means of its complex interactions with the cells and with the other components of the extracellular matrix. Very recent studies have shown that the CD44 receptor is the main target of hyaluronic acid. Following this interaction, a number of physiological events are triggered off which include: cell-cell adhesion, cell-substrata adhesion, migration, cellular proliferation activation and the uptake and degradation of hyaluronic acid. The main functions of the CD44 receptor:   - to regulate the mechanisms linked to the inflammatory response - to regulate the proliferation of keratinocytes in response to extracellular stimuli - to maintain the homeostasis of hyaluronic acid 27 11

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Properties - Compacting action - Elasticizing action - Fibroblast stimulation activity   Inhibition of the cholinergic transmission   Regulation of the inflammatory response by the cd44 receptor - Acetyl Glutamyl Heptapeptide-1 Peptide with a Botox-like action, due to its property similar to that of botulin, but without any of its side effects. Its action is performed by acting directly on muscular transmission, helping the muscles, which are perennially contracted in the areas with lines of expression, to relax. - - Seawater - Vitamins E C and F - Provitamin B5 Emulsion riche en mesure de garantir une réduction des inesthétismes liés aux bourses et aux cernes. Sa texture douce et soyeuse offre à la peau une sensation de fraicheur et transmet un bénéfice immédiat. La complémentarité parfaite des actifs sélectionnés par Medicallife a permis d’atténuer le phénomène à différents niveaux avec une action complète et efficace. Eine reichhaltige Lotion, die eine Linderung von Hautproblemen wie Tränensäcken und Augenringen gewährleistet Die weiche und geschmeidige Texture schenkt der Haut ein Gefühl von Frische und vermittelt eine sofortige, wohltuende Wirkung. Dank des optimalen Zusammenwirkens der von Medicallife ausgewählten Wirkstoffe lässt sich dem Phänomen umfassend und effizient entgegenwirken. Gözaltı torbaları ve mor halkalara bağlı estetik kusurları azaltmayı garanti eden zengin emülsiyon. Yumuşak ve esnek dokusu sayesinde anında bir rahatlama sağlayarak, cilde tazelik hissi kazandırır. Medicallife tarafından seçilen aktif maddelerin mükemmel sinerjisi komple ve etkin bir eylem ile muhtelif seviyelerdeki kusurlarla mücadele etme imkanı tanır. Gözaltı torbaları ve mor halkalara bağlı estetik kusurları azaltmayı garanti eden zengin emülsiyon. Yumuşak ve esnek dokusu sayesinde anında bir rahatlama sağlayarak, cilde tazelik hissi kazandırır. Medicallife tarafından seçilen aktif maddelerin mükemmel sinerjisi komple ve etkin bir eylem ile muhtelif seviyelerdeki kusurlarla mücadele etme imkanı tanır. 28 12

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Anti-wrinkle Serum Face Neck Anti-wrinkle Serum Face Neck Eye Eye Contour Contour exclusive patented - An anti-wrinkle serum, formulated thanks to an innovative technique, for high impact sensory perceptions, whilst guaranteeing maximum functionality. Recommended in particular for the most demanding clients, who want maximum results in the shortest time possible from an anti-wrinkle product. ACTIVE INGREDIENTS AND RESULTS - Edelweiss plant stem cells - Gardenia plant stem cells Highly perfumed and a symbol of elegance, the Gardenia has been the image of a refined way of life; th imported from China around the middle of the 18 century, it owes its name to the naturalist Alexander Garden and its scent is similar to that of jasmine. - The Gardenia has invaluable secrets that are helpful in countering the signs of time and Medicallife, using stem cells, has succeeded in capturing these properties, concentrating them and keeping them active. The properties of the Gardenia include reducing the formation of MMP1, which are enzymes involved in the degradation of collagen. 33 13

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These enzymes normally increase due to ageing, but in the case of cigarette smoke and exposure to the sun, they are further stimulated. The Gardenia stem cells used by Medicallife contribute to bringing this altered situation back to normal. The effect on the release of MMP1 has been of the inhibitory type, confirming the anti-ageing capacity of the Gardenia. The tests were carried out on cultures of human fibroblasts. The capacity to inhibit collagenase (the enzyme involved in the degradation of collagen) and to stimulate the formation of new collagen was demonstrated in vitro, with a dose-dependent action. PROPERTIES: - it stimulates the synthesis of new collagen - it reduces the degradation of collagen by MMP, - it inhibits the synthesis of collagenase, the enzyme which destroys collagen. - Acetyl Octapeptide-3 Botox-like peptides are the current remedy against the formation of wrinkles. Medicallife, which has always been to the fore in innovation, has included the latest discovery in the field of peptides to guarantee maximum effectiveness and safety in the Manù anti-wrinkle eye contour. The smoothing action is guaranteed by the inhibitory effect on the release of acetylcholine, due to the competitive action with the SNARE complex, a protein system of activating the release of acetylcholine from the interneuronal vesicles. Compared to its competitors, Acetyl Octapeptide (in the green box below) has shown its capacity to reduce the formation of the SNARE complex. The in vitro effect reported was also confirmed in vivo: the tomographic analysis on an area with wrinkles showed a maximum reduction in the depth of the wrinkle of 63%. 34 14

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